Tuberculosis Lymphadenitis Among Hiv-positive Individuals And Its Correlation To Cd4 Count Cytomorphological Pattern And Clinical Diagnosis In Mekell University Ayder Comprehensive Specialized Referral Hospital

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Background: Tuberculosis is the second leading cause of death from infectious disease globallyrnwith its impact more dramatic in resource limited settings. Individuals with humanrnimmunodeficiency virus infection who also develop tuberculosis represent a significantrnchallenge to TB control. HIV not only increases the number of TB cases, but also alters thernclinical course of TB disease. As HIV related immunosuppression increases, the clinical patternrnof TB changes, with increasing numbers of smear-negative and extrapulmonary cases.rnLymphadenopathy is one of the most common manifestations at any stage of HIV/AIDS withrndifferent underlying pathogenesis. Tuberculous Lymphadenitis is the most common form of rnextrapulmonary TB and typically presents with asymmetric involvement of multiple nodes 1 cmrnor larger in size. Cervical and axillary nodes are most frequently affected.CD4 T cells playrncentral roles in the function of the immune system and are important mediators of immunologicrnmemory,rnObjective: the objective of this study is to determine the prevalence of tuberculosisrnlymphadenitis infection among HIV/AIDS positive patients and its correlation to CD4-count,rnmorphological patterns and clinical Diagnosis.rnMethod: A cross sectional study design was conducted from January 10/2019 to July 10/2019. Arntotal of 90 HIV positive patients who develop lymph node were enrolled into the study byrncontacting the patients during their visit to the ART clinic. Socio -demographic characteristicsrnand other variables were collected using a pretested semi-structured questionnaire. Detailedrnclinical history and laboratory investigations were considered in all patients. The statisticalrnsoftware and methods including the level of statistical significance were explained and employedrnfor data analysis and interpretation. The results were then analyzed statistically using thernstatistical package for social sciences (SPSS) version 23 for Windows.rnResult: Maximum number of tuberculosis lymphadenitis is seen in the age group of 21-30 yearsrnfollowed by age group of 31-42 and with a decreasing trend in elderly. There was a femalernpreponderance of cases. Most cases of Tuberculosis lymphadenitis emerged as the 2nd mostrnfrequent Cytomorphological pattern of diagnosis next to reactive lymphoid hyperplasia to bernassociated with HIV infection With the typical caseous necrosis and Epitheloid granuloma.CD4rncount

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Tuberculosis Lymphadenitis Among Hiv-positive Individuals And Its Correlation To Cd4 Count Cytomorphological Pattern And Clinical Diagnosis In    Mekell University Ayder Comprehensive Specialized Referral Hospital

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