Background: List of disease entities affect the lung, with surgically removed masses accountingrna large share in proportion. A variety of neoplastic and non-neoplastic lesions are under thisrncategory. Results of several studies show neoplastic lesions account for the largest share amongrnresected specimens. From the neoplastic lesions, malignancies are the most common ones;rnfrom these primary tumors (carcinomas) are the leading. Benign tumors are very rarerncompared to the malignant ones, hamartoma being the most common among the benignrncategory. According to the 2018 WHO report, lung cancer is the most cancer (2.09 millionrncases) and the leading cause of death (1.76 million). According to the Globocan report on thernincidence and prevalence of cancer in Ethiopia by 2018, Lung cancer ranks the 7rn mostrncommon malignancy in Ethiopia. Addis Ababa population-based pattern of cancer therapy,rnfound out that lung cancer ranking as the 5rnthrn most common malignant tumor. rnObjectives: The aim of this study was to determine the frequency and histopathologic patternsrnof lung lesions with clinicoradiological features in resected specimens diagnosed in TikurrnAnbessa Hospital. rnMethods and materials: Retrospective study was conducted on five years biopsy reports ofrnneoplastic and non-neoplastic resected lung lesions submitted from January 01, 2016 to Augustrn30, 2020. Data had been retrieved from the archive of the department of pathology. Clinicalrnpresentation and gross description of the lesions was collected from the patientâ€™s originalrnbiopsy request. Final data analysis was done using latest SPSS version 25. rnResults: From a total of 170 cases reviewed 159 cases fulfilled the study criteria and included inrnthe study. From these, 99 (62.3%) of the study subjects were males while the remaining 60rn(37.7%) were female. M:F ratio of 1.65:1. The minimum age was 2 month and the maximumrnage was 73 year. Mean age of patients was 36.8 year. There were 92 (57.9%) non-neoplasticrncases and 67 (42.1%) neoplastic cases. The commonest age group for both neoplastic and nonneoplasticrnlesionsrnrnwerern3rnrdrn and 4rnthrn decades. Cough and hemoptysis were the commonestrnclinical presentation (n = 39, 24.5%). The commonest radiologic finding was mass 37 (23.3%).rnLobectomy was the most common surgical procedure performed (n=97, 61 %) followed byrnpneumonectomy 38 (23.9%). Bronchiectasis was the most common non-neoplasticrnhistopathologic entity 18 (11.3%) cases, followed by aspergillosis 16 (10.1%) cases. Out of thern67 neoplastic cases, only 5 (7.5%) cases were benign the rest 62 (92.5%) were malignant. All thernbenign tumors were hamartoma. The malignant cases had a M:F ratio of 1.06:1. Typicalrncarcinoid was the most common histopathologic type reported (45.2%), followed byrnadenocarcinoma (25.8%), SCC (9.7%). Majority of the malignant neoplasms were in pathologicrnstage II (55.2 %). There were 31 (53.4%) cases with known lymph node status. From these, 58.1rn% had up to 3 LNs and 25.8 % had up to 4-6 LNs examined with majority had N0 (34.5%) casesrnand N1 (15.5%) cases.rnConclusion: In this study a higher proportion of non-neoplastic lesions were identified inrnresection specimens than neoplastic cases. Carcinoid tumor was the most frequentrnhistopathologic subtype.rnth