Background- HIV/AIDS is a major crisis that is increasingly affecting the most productivernsegments of the population in sub-Saharan African countriesrnObjective- the main objective of this study is to determine the knowledge, attitude and practicernof HIV/AIDS prevention methods among commercial sex workers in Alamata woreda, Tigray,rnEthiopia 2013.rnMethodology- Community based cross sectional study was conducted in Alamata woreda,rnTigray . Those who practice sex work in their home were included in the study using purposivernsampling. Data were collected by interviewer administered semi-structured questionnaire andrnentered using Epi info version 3.4 software and exported to SPSS software version 16 forrnanalyses. Frequencies, percentage, chi-square with p-value were used to describe the studyrnpopulation in relation to relevant variables. The degree of association between independent andrndependent variables were assessed using crude odd ratio with 95% confidence interval.rnConsecutively multiple logistic regression analysis was performed to control the potentialrnconfounding variables under the study.rnResults- Of those 106 participants 69(65.1%) were from the surrounding rural areas, 49(46.3%)rnwere young aged between 15-25 years old with mean age of 23yrs and 96.2% of them werernhighly knowledgeable. All of the study participants (commercial sex workers) were mostrnvisited (had frequent sexual practice with) farmers. As shown in this study, 24.5% of therncommercial sex workers reported as AIDS can be cured. The multivariate logistic regressionrnanalysis shows only place of origin was significantly associated with consistent use of condom.rnConclusion - The high level of information and knowledge about AIDS seem to have littlernimpact than the expected. Therefore, level targeted interventions towards sex workers and theirrnclients can reduce HIV risk and vulnerability as well as reduce the number of new HIV infectionsrnamong sex workers and the general populations.rnRecommendation - The ministry of health and other concerned bodies should have effectivernHIV & STIs programs based on clear understanding of â€œ who the sex workers are, where the sexrnis practiced, and who their frequent clients are