Background: Percutaneous exposure incidents (PEIs) and blood splashes on the skin of healthrncare personnelâ€™s are a major concern worldwide. It exposes the healthcare personnel to the riskrnof infectious diseases.rnObjective: this study was designed to assess percutaneous exposure incidents (PEIs) andrnassociated factors among health care personnel in Gandhi Memorial hospital, Addis Ababa,rnEthiopia.rnMethods: Institution-based quantitative cross-sectional study design was utilized involving 244rnstudy subjects using systematic random sampling technique. The data was collected using arnstructured self-administered questionnaire & interview based data collection technique.rnAnalysis: The data was compiled, cleaned and entered into a computer software using Epi Datarn3.01 and then exported to statistical package for social sciences (SPSS) version 20.0 for analysis.rnThe descriptive statistics includes frequencies, proportions and means were computed. Bivariaternand multivariate logistic regression were also computed to assess statistical association betweenrnthe outcome and selected independent variables using odd ratio, significance of association usingrn95% confidence interval and P-value (40 hours per week was found to be associatedrnwith the chance of sustaining NSI compared with those worked for less than 40 hours per weekrn(AOR=9.80,95%CI=2.68-35.83 P-value=0.02). In line with this finding, respondents with workingrnhour >40 hours per week were also found to be 6 times more at risk to blood and body fluidsrnsplash exposures compared with those worked for less than 40 hours (AOR=5.85, 95%CI=1.29-rn26.6, P-value=0.02).rnConclusion and Recommendation: The findings of this study indicated that occupationalrnexposures were common among healthcare workers, including accidental needle-stick, cuts withrncontaminated instruments and blood splashes. The highest proportion of needle stick injuriesrnamong health care personnel were related to administration of injection, followed by recappingrnof needles. Auxiliary staff had the highest prevalence of sharp injuries, blood and body fluidsrnsplash from all healthcare personnel. The hospital should incorporate auxiliary staffs on trainingrnabout infection prevention. Furthermore reducing the working hour or heavy work over load wasrnalso advantageous to healthcare workers.rnKey words: Occupational exposure, percutaneous exposure incidents, needle-stick injuries,rnhealth care personnel