Background: Breast cancer is a disease of public health importance. It results in high morbidityrnand mortality in women worldwide. Breast examination as a screening tool for breast cancer inrndeveloping countries is advocated in view of its cost-effectiveness.rnEarly detection of breast cancer using breast self-examination (BSE) plays an important role inrndecreasing its morbidity and mortality.rnObjective: To assess breast cancer awareness and practice of breast self-examination amongrnfemale students in Madawalabu University Bale, Ethiopia, 2014rnMethods:rnCross-sectional study design was employed from December â€“June, 2014 inrnMadawalabu University.rnFirst the students were divided in to two practical strata, which are health science students andrnnon-health science students. From each stratum, participants were selected by simple randomrnsampling based on the proportion of the number of female students in each stratum that was 39rnhealth science students and 383 non- health science students.rnSelf administered questionnaire was used to collect the data. Data were entered with Epi Infornversion 3.5.1 and analyzed using SPSS statistical package version 16.0. Bivariate andrnmultivariate logistic regression analysis was performed.rnResult: This study found that only [31.0%] of students had awareness about breast cancer andrn[15.5%] practiced BSE. The three main reasons for not doing BSE were belief that there is nornproblem with their breast [50.8%], not knowing the technique of BSE [40.0%], and Lack ofrnprivacy [15%].rnAwareness about breast cancer and got information about BSE by health professionals werernfound significantly associated with practice of BSE. Respondents in the health related disciplinesrnwere six times more likely to practice BSE than other respondents.rnConclusion: Awareness of breast cancer and BSE practice was found low in this study. Havingrninformation on the importance of BSE was predictor of BSE practice