Background: Death related to unintended pregnancy associated events is a series publicrnhealth concern in Ethiopia. This is very common in young adolescents for whom life is fullrnof adventure and temptation with very little knowledge about the consequences of theirrnreckless activities. Emergency contraceptives are the only method that can be used withinrnshort time after sexual intercourse, offering a second chance to prevent unwantedrnpregnancy. Emergency contraceptive will have contribution in decreasing maternalrnmortality and morbidity due to unwanted Pregnancy & its sequel.rnObjectives: To assess the knowledge, attitude and practice of emergency contraceptivesrnamong female college students at Mekelle town, Ethiopia.rnMethods: An institutional based cross-sectional survey was conducted among 616 femalerncollege students at Mekelle town from January to May, 2011. Multistage samplingrntechnique with Probabilities proportional to size was used. Data were analyzed by SPSSrnwindow version 16.0 soft ware package and presented using frequencies, percentages,rncrude odds Ratio, 95% Confidence Intervals and multiple logistic-regressions to adjust forrnpossible confounding variables.rnResults: Of the total respondents, 393(67.3%) of them replied that they have heard aboutrnemergency contraceptives. Among those who have ever heard of emergencyrncontraceptives, 224 (57%) mentioned pills only, 9 (2.3%) mentioned intrauterinerncontraceptive devices (IUCDs) only and 154(39.2%) mentioned both pill & IUCDs.rn263(45%) of the respondents were knowledgeable towards ECs, and about 271(46.4%) ofrnthe students had positive attitude towards emergency contraceptivesrnOf the sexually active respondents 70(24.2%) only reported that they had used emergencyrncontraceptive methods previously. Whereas, 219(75.8%) were not used emergencyrncontraceptives; some of the reasons were lack of knowledge about ECs (42.9%); no desirernto use (22.8%) and inaccessibility toward emergency contraceptives (16.4%).rnConclusion: The study indicated low level of knowledge; very low practice and majorityrnshowed negative attitude towards emergency contraceptives