Background: Proper handwashing is one of the simplest, most affordable and effective means ofrnpreventing the spread of infection. Studies have recommended handwashing as the best means ofrndiarrheal disease and respiratory tract infections prevention. Handwashing among school childrenrnis influenced by different factors like socio-demographic, predisposing, reinforcing and enablingrnfactors. However, these factors may have not been studied well among school children asrncompared to other classes of population.rnObjectives: To assess handwashing practice and associated factors among primary school childrenrnin Sebeta town, Oromia Regional State, Ethiopia.rnMethodology: Institutional based analytic cross sectional study design was employed on primaryrnschool children in Sebeta town. Data on handwashing practice and associated factors wererncollected from 426 sixth- through eighth-grade students in 6 schools via self-administeredrnquestionnaires. School hand washing facilities inspection were also done using observationrnchecklist.rnResult: Only one-third (32%) of participants fulfilled the criteria of proper hand washing practicerni.e. washing hand with soap always or very often before meal and after visiting toilet. Studentsrnwith positive attitude were more likely to practice proper handwashing (AOR=2.29;rn95%CI=1.43, 3.66).Likewise, those who felt pressure from their important referent were tworntimes more likely to wash their hand (AOR=1.86; 95%CI=1.02, 3.16). Availability andrnaccessibility of soap for hand washing was also strongly associated with handwashing practicern(AOR=3.0695%CI=1.32, 7.05). On the other hand students from rural areas were less likely tornpractice proper hand washing than their urban counter part (AOR=0.53; 95%CI=0.30, 0.94).rnConclusion and recommendation: In general this study revealed that only small proportion ofrnstudy participant practiced proper hand washing behavior and absence of adequate hygienernfacility in visited school. Place of residency, attitude, and pressure from important referents andrnregular access to soap were significantly associated with hand washing. Provision of adequaternhygiene facility, further modification of attitude towards handwashing with soap and rolernmodeling is recommended