Background: -Patients with hypertension are at high risk of cardiovascular disease. Anrnincrease of 10 mm Hg (more than normal) in diastolic blood pressure leads to relativelyrnincreased risk of stroke and cardiovascular disease up to 37%. Moreover, hypertension mayrnimpair vision. The symptoms range from blurred vision to blindness. Since it is a chronicrndisease, that necessitate lifelong drug intake and changes in lifestyle. A lack of knowledgernabout hypertension negatively influences patientsâ€™ awareness and behaviors, and is a majorrnobstacle in controlling hypertensionrnObjective the general objective of the study was to assess over-all level of knowledge,rnself-care and its associated factors among hypertensive patients in adult cardiac and renalrnreferral clinic in public hospitals Addis Ababa city Administration Addis Ababa Ethiopia.rnMethod â€“ Institutional based cross sectional study was conducted in five public healthrnhospitals (Yekatit 12, Ras Desta Zewuditu, Dagmawi Menilik and Tirunesh Bejing). Thernfinal sample size is 384 which was proportionally allocated to each of the institutions andrnsystematic random sampling was used to select study units that was part of the study. Datarnwas checked, cleaned and entered in to Epidata software, then imported to SPSS versionrn20.0 software for analysis. The results of the descriptive statistics were expressed asrnpercentage and frequency. Associations between independent variables and dependentrnvariables was analyzed using bivariate and multivariate analysis to identify factors whichrnare significantly associated with knowledge; self-care practices among hypertensive patientrnwho had follow up in the hospitalsrnResult: - Data coming from this study reveals that (43.6%) of study participants has goodrnknowledge about hypertension. It also indicated that there is a strong association betweenrnknowledge about hypertension and educational status, family history of hypertension, placernof residency and occupational status of the study participants. On the other hand, the studyrnshows that (51.5%) of study participants has good self-care practice towards hypertension.rnHowever, there is a significant association between self-care practice and place ofrnresidency and educational status of the study participants. Study participants who hasrnsecondary and above educational status has good self-care practice than participants havernno formal education.rnConclusion: - Despite the important role of knowledge and self-care practices inrnmanagement of hypertension were recognized to be useful and effective in achievingrnhypertension control and preventing its complication, findings of this study were confirmrnprevious findings concerning self-care among people with self-care practice wasrnaccomplished as recommended in majority respondents but knowledge was morernproblematic.rnRecommendation: - Family members should be informed about their important roles inrnencouraging patients to undergo a hypertension control or self-care practices.it is alsornrecommended that Health care personnel must increase patientâ€™s awareness toward thernimportance of all types of self-care practices domains and strongly promote the practicernamong hypertensive patients via strengthening IEC program, hypertension association.rnKey words: -hypertension, knowledge, self-care practice and factors