Background: Pregnancy complications are the major health problems among women inrndeveloping countries. Approximately 529,000 women die from pregnancy related causesrnannually and almost all (99%) of these maternal deaths occur in developing countries.rnObjective: To assess knowledge, attitude and practice of mothers towards obstetric danger signsrnduring pregnancy in Debre Birhan City Administration, April, 2014.rnMethods: A community based cross-sectional quantitative study was conducted in April,2014, onrna sample of 634 mothers who are at least 4 months pregnant for primi gravid and delivered inrnthe past 24 months selected from, 4 urban and 2 rural Kebeles of Debre Birhan cityrnAdministration. Multistage sampling technique was employed to select the study participants.rnResults: A total of 634 mothers were enrolled in the study giving a response rate of 99.7%. Thernstudy participants from selected urban kebeles constituted 76.7%. Most (68.2%) of the studyrnparticipants were found to have poor knowledge. Respondents who got obstetric danger signsrninformation from media had 2.8 times good knowledge than those respondents who didnâ€Ÿt getrninformation from the same source [AOR=2.8, 95%CI (1.7- 4.65)].52.7% of the study participantsrnhad negative attitude. Participants who had formal education have 2.2times positive attitude thanrna participants who had informal education [AOR=2.2, 95% CI (1.1- 4.4)].Out of 51(8.1%) whornexperienced obstetric danger signs 44(7.0%) had Good practice.rnConclusion: Knowledge and attitude of study participants are not satisfactory (68% poorrnknowledge and 52.7%) the practice of the study participants who had experienced obstetricrndanger signs during pregnancy was good.rnRecommendation: Awareness of key danger signs needs to be given priority as it preparesrnwomen and their families for timely and appropriate decisions and action in case of obstetricrndanger signs.rnKey words: Danger signs, Pregnancy, Obstetric care