Background Preterm birth is alive childbirth before 37 completed weeks or 259 days ofrngestation from the first date of a woman's last menstrual period. About 15 million babies arernborn preterm annually and more than a million died due to complications. Preterm birth ratesrnappear to have increased over time and the exact cause of preterm birth is unknown withrndifferent risk factors are assumed to have an association. Objective The objective of the studyrnwas to assess determinants of preterm birth among newborns in public hospitals of Hawassarntown, Southern Ethiopia, 2020.Method A Facility-based unmatched case-control study designrnwas conducted from March 1rnstrn to June 30rnthrn, 2020.The sample size was determinedfromrnprevious studies by considering double population proportions formulausing r = 2 (ratio ofrncases to controls), 80% power and 95% confidence level and total sample size was270rnmothers 90 cases and 180 controls. Consecutive sampling method for cases and systematicrnrandom sampling controls were used.Data was coded and entered into Epi data 3.1 andrnanalyzed by using SPSS version 25.Variables that had (P- value