Treatment Outcome Of Diabetic Ketoacidosis And Its Determinants Among Children Admitted In Debre-tabor And Gondar Referral Hospital Ethiopia A Retrospective Study.

Background: -Diabetic ketoacidosis represents a state of acute metabolic stress that occurs duernto absolute or relative insulin deficiency for metabolism of glucose. It causes 0.15-0.35% deathrnof children in developed countries and 3.4-13.4% in developing countries.rnObjective: To assess the treatment outcome of diabetic ketoacidosis and its determinants amongrnchildren with DKA in Debre-tabor and Gondar Referral Hospitals, North-West Ethiopia, 2021.rnMethods: Institutional based retrospective cross sectional study was conducted with sample sizernof 244. Systematic random sampling method was applied to select the study subject. The datarnwas collected by using checklist in the medical record. The collected data was coded and enteredrnin Epidata version 4.6 and was transferred to SPSS 25 for further analysis. Bivariate analysis wasrndone and all independent variables which have association with the outcome variable at p-value rn0.25 were entered in to multivariable model. A p-value 0.05 was considered as a cut of valuernto indicate statistical significance. rnResult: In this study a total of 240 DKA children with response rate of 98.4%) were included.rnFrom these, 86.7% of them recovered and 13.3% died. Respiratory tract infections (AOR=3.5;rn95%CI;1.2-10), sepsis (AOR=4.9; 95%CI;1.45-16.57), cerebral edema (AOR=5.89;95%CI;1.5622.3),renalrnrnfailure (AOR=3.6;95%CI;1.06-12.45), hyponatremia (AOR=4;95%CI;1.02-16.1),rnhypernatremia(AOR=7.4;95%CI;1.29-42.08),vomiting(AOR=3.4;95%CI;1.06-10.8),dehydrationrn(AOR=4; 95%CI;1.15-14.03) and not giving potassium replacement therapy (AOR=7.4;rn95%CI;1.29-42.08) were significant associated factors for death of children with DKA. rnConclusion and recommendation rnIn general, the overall mortality of children with DKA was 13.3% in this study. The majorrnassociated factors for death of children with DKA were vomiting, dehydration, hyponatremia/rnhypernatremia, Respiratory tract infections, sepsis, renal failure, cerebral edema and potassiumrntherapy. So that early diagnosis and treatment of the above factors are necessary to prevent deathrnof children with DKA.

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