Antiplasmodial Activity Of Extracts From Dodonaea Angustifolia L.f. And Bersama Abyssinica Fresen Against Plasmodium Berghei In Mice Model

The seed of Dodonaea angustifolia and root bark of Bersama abyssinica are traditionally used for the treatment/prophylaxis of malaria in some malarous areas in Ethiopia. The aim of this study is to evaluate antiplasmodial activity and study acute toxicity of Dodonaea angustifolia and Bersama abyssinica in P. berghei infected mice. In the present study, aqueous and methanol extracts of D. angustifolia and B. abyssinica were investigated for their antimalarial activity using Peters’ 4-day suppressive test against P. berghei infection in mice. The crude extracts and the fractions of the most active extract were orally administered to screen their antimalarial properties. The extracts significantly inhibited parasitemia and prevented PCV fall (p

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