Evaluation Of The Diuretic Activity Of The Aqueous And 80 Methanol Extracts Of The Leaves Of Cucumis Dipsaceus Ehrenb (cuccurbitaceae) In Rats

Diuretics are drugs, which increase the excretion of electrolytes and water from the bodyrnby an action on the kidney. Their primary effect is to decrease the re-absorption of saltrnfrom the filtrate and increase water loss. They are used primarily to prevent and alleviaternfluid overload like edema and ascites. C. dipsaceus leaf is one of medicinal plantsrnclaimed to have diuretic activity in indigenous system of medicine, but has not beenrnscientifically evaluated. Therefore, the present study was done to evaluate the diureticrnactivity of the aqueous and 80% methanol extracts of the leaves of C. dipsaceus in rats.rnMale rats were randomly divided into eight groups (six rats per each group): negative andrnpositive control groups, three different groups per each extract for different doses. Thernvolume of urine output, urinary electrolyte concentration (Narn+rn, Krn+rn, and Clrn), and urinaryrnpH were measured and analyzed to make comparison among the groups. Both thernaqueous and 80% methanol extracts significantly increased the urinary output atrn200mg/kg (p

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