Evaluation Of Anti-gastric Ulcer Activity Of Aqueous And 80 Methanol Leaf Extracts Of Urtica Simensis In Rats

In Ethiopian traditional medicine, the leaf of Urtica simensis is used in the treatment of gastric ulcer. Since this claim has not been investigated scientifically, this study was undertaken to evaluate the anti-gastric ulcer activity of both aqueous and 80% methanol extracts of Urtica simensis. The aqueous and 80% methanol leaf extracts of Urtica simensis were prepared using decoction and maceration techniques of extraction respectively. Three models, pylorus ligation, indomethacin and ethanol induced gastric ulcer models were employed to assess the anti-secretory and mucoprotective potential of the extracts. Three dose levels (100, 200, and 400 mg/kg) were employed for each extracts. Negative control received distilled water, whereas positive controls were given cimetidine 100 mg/kg. In pylorus ligation induced gastric ulcer model, both types of extracts at dose of 200 &400 mg/kg were exhibited significant reduction in total acidity, volume of gastric secretion (p

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