Physicochemical Characterization Of Native Cellulose And Microcrystalline Cellulose From Enset Fiber And Evaluation Of Microcrystalline Cellulose As Directly Compressible Excipient

Cellulose is naturally occurring polymer on earth and it is obtained from wood, cotton, agricultural residues and different fibrous plants. Enset (Ensete ventricosum) is a plant indigenous to Ethiopia. It is serves as food, forage, fiber and medicinal uses. Enset fiber is a rich source of cellulose. The aim of this study was to extract and characterize native cellulose and microcrystalline cellulose (MCC) from enset fiber and evaluate MCC as directly compressible excipient. Cellulose was extracted by using formic acid/acetic acid (at 70:30 ratio). Different enset fiber MCCs were prepared by using hydrochloric acid. The proximate yield of enset fiber cellulose (Ef-C) and enset fiber microcrystalline cellulose (Ef-MCC) were found to be 56.97% and 65.42-82%, respectively. The degree of polymerization (DP) of Ef-MCC powders were less than 350. Fourier Transform Infra-red spectra (FT-IR) of Ef-MCCs indicated the typical absorption peaks of cellulose.rnThe physicochemical studies of Ef-MCCs revealed, moisture content of

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