Chronic kidney disease (CKD)is the reduction in the Glomerular Filtration Rate (GFR) andrnurinary abnormalities or a structural abnormality of renal tract which is explained by pathologicrnkidney abnormalities, persistent proteinuria, and other urine abnormalities on two occasionsrnseparated by >90 days. As kidney function declines, number and complexity of medicationrnincrease with the progression of the disease. Due to this Patients with this disease are at high riskrnfor medication-related problems because of their condition and the multiple medications requiredrnfor treatment of the causative disorders, and the complications associated with the disease. Thisrnstudy aimed at establishing the extent of medication related problems among patients with chronicrnkidney disease as well as exploring associations of different covariates with the problem identified.rnHospital based cross-sectional study was conducted among ambulatory patients with chronicrnkidney disease at St. Paulâ€™s Hospital Millennium Medical College, Addis Ababa, Ethiopia from 1rnof June to 30rnthrnof August 2019. Patient with chronic kidney disease stage 1, 2, 3, and 4 adultrnambulatory patients were included in the study. A total of 325 medication related problems werernidentified from 204 (82.3%) study participants giving 1.6 MRPs per participants. One medicationrnrelated problem was identified in 114 (55.9%) patients while two in 64 (31.4%). From the totalrnof identified problems most common class of MRP identified were need additional drug therapyrnproblems 114 (35.1%) followed by non-compliance 54 (16.6%). This study showed that onlyrnoccupation (AOR=5.2, 95% CI: 1.292-21.288, P=0.020) and Angiotensin converting enzymerninhibitor (ACEI)use (AOR=6.6, 95% CI: 2.202-19.634, P=0.001)had association with thernoccurrence of medication related problems. In general, our study suggest that medication relatedrnproblems experienced by each chronic kidney disease patients were high. In terms of types ofrnMRPs, this study showed that need additional drug therapy was frequently identified types.rnst