Background: The Pharmaceutical logistics system in Ethiopia is consistently hindered by rnseveral systemic problems that cause frequent stockouts of critical pharmaceuticals. It is rneven worse when it comes to the supply chain management of neglected tropical diseases, rnincluding leishmaniasis. rnObjective: To assess leishmaniasis treatment commodit iesâ€™ management and treatment rnpattern in public health facilities of Amhara Region. rnMethod: A descriptive cross sectional survey design was used for the study and a total of rn18 health facilities found in Amhara Regional State were included in the study. rnInformation on availability, inventory and storage practices of leishmaniasis treatment rncommodities and treatment pattern from health facilities were collected using structured rnquestionnaires. In addition, in-depth interviews with key informants were conducted to rnidentify challenges on leishmaniasis treatment commodities, and treatment pattern using rninterview guide. Three data collectors were trained and involved in data collection rnprocess. Data was entered and analyzed using Statistical Package for Social Sciences rn(SPSS) version 20. Descriptive statistics were used to calculate mean and percentage rnfigures. The qualitative data was transcribed and summarized thematically. rnResults: Utilization of bin cards and Receiving and Requisition Form (RRF) for rnleishmaniasis treatment commodities were reported in 10(55.6%) of the facilities, rnwhereas 11(61.1%) health facilities used Internal Facility Report and Resupply (IFRR) rnfor leishmaniasis treatment commodities. Fourteen (77.8%) and 7(38.9%) of the health rnfacilities experienced stockouts of one or more commodities during the past one year and rnon the day of the visit, respectively. Five (100%) and 10(62.5%) facilities were stockout rnwith mean frequency (range) of stockout 3.6(3-4) and 1.6(0-3) for Amphotericin B and rnrk39 test kit in the past one year, respectively. The mean number of days (and range) of rnstockouts of health facilities were 86(0-160) for Sodium Stibogluconate and 153(128-rn192) for Amphotericin B in the study period (March 2018-Feburary 2019). A total of rn18221 leishmaniasis suspected patients in a period, from January 2016- December 2018, rnwere tested by rk39, aspiration, and skin smear test, out of which 6261 were positive. Out rnof 6261 total leishmaniasis positive cases, the highest annual prevalence, 2414(38.6%), rnwas reported in 2018. In the Amhara Region, 1245 in 2016, 1169 in 2017, and 1349 in rn2018 leishmaniasis cases were managed. Out of 1147 patients with leishmaniasis treated rnin the study facilities in the period (March 2018-Feburary 2019) 122(76.2%) and rn317(83.9%) were treated with Amphotericin B and combined Sodium Stibogluconate rnwith Paromomycin for recommended duration respectively whereas 4(33.3%), and rn155(26%) of patients treated with Paromomycin and Sodium Stibogluconate rnmonotherapy were below the recommended duration respectively. The highest co-rninfection with leishmaniasis in the study period (March 2018-Feburary 2019) was severe rnacute malnutrition which is 38 patients. Out of the received leishmaniasis commodities, rn5% of Sodium Stibogluconate, 8.6% of Paromomycin, and 7% of rK39 test kit were rnexpired in the study period (March 2018-Feburary 2019) while 69.3% and 35.8% of rK39 rntest kit and Paromomycin from stock on hand were near expiry. From the total assessed rnfacilities, two hospitals, 88.2%, and 94.1% perform storage condition guideline criteria rnwhich is above the recommendation, and only 11.11% of health facilities maintain rnacceptable storage conditions. rnConclusion: The majority of health facilities had poor inventory management practice rnfor leishmaniasis treatment commodities. Most health facilities experienced one or more rncommodities stocked out at the time of the visit and during the past year preceding the rnsurvey. Amphotericin B was the most frequently stocked out commodity in the health rnfacilities. Some patients took treatment below the recommended duration which is rncontrary to established treatment guideline protocol. The storage condition of most health rnfacilities was inadequate, and there was an expired and a large number of near expiry rnproducts in the health facilities. Generally, there was poorly organized leishmaniasis rntreatment commodities management in the region.