Targeting drug delivery into the colon is highly desirable with many advantages including localrntreatment of a variety of bowel diseases and systemic delivery of protein and peptide drugs.rnResearch studies propose the use of resistant starch to serve as part of a targeted drug deliveryrnsystem to the colon where it gets digested by the local bacterial enzymes. rnConsidering this natural phenomenon, in this study Teffâ€™s resistant starch has been evaluatedrnas a film coating material for colon targeted drug delivery system (CTDDS) for the first time.rnTeff (Eragrostis tef) is a native cereal crop widely grown in Ethiopia. It has 73 % carbohydratesrnand out of the total starch around 30 % is resistant starch. rnThe whole work includes the main steps of extraction of starch from teff and resistant starchrnfrom the total starch, preparation of a film coating material using the resistant starch andrncoating a sample tablet with the film-forming material, finally testing the film-coated tablet ifrnit could pass the upper GIT intact to release the drug in the colon under simulated in vitrornconditions. rnDifferent methods were used to achieve the above objectives including The methods byrnBultosa et al. (2002) and Gebre-Mariam and Schmidt, (1998) for total starch isolation. Whilernin the isolation of RS the AOAC official method 2002.02 and for the tablet coating process thernmethod described by Siew et al, (2000) was used. rn In the preparation of the film coating material from the resistant starch for CTDDS, becausernof resistant starch dominant part amyloseâ€™s property of swelling when it gets in contact withrnwater, a water-insoluble polymer Ethylcellulose (EC) was used and managed to control thernpremature film dissolution before reaching the colon. rnTo get the optimum combination of amylose and EC for a film coating solution, their differentrnratios and film thickness (expressed in percentage total weight gain of the tablet) have beenrnprepared and tested in a simulated gastrointestinal condition as per the standardrnpharmacopoeia of the model drug, Metronidazole tablet. rnIn the study, as per the result of dissolution and fermentation data, the best film materialrnproportions of amylose to EC and the corresponding thicknesses in percentage total weightrngain identified were; the ratio of 1:1 with thickness 6%, ratio of 1:2 with thickness 4 % and 6%,rnand finally ratio of 1:3 with thickness 2% and 4%. These were found to be the optimum filmrnthicknesses and combination of the film coating materials to release the drug in the colon butrnnot in the upper GIT. rnThe reason behind the site selected (targeted) drug release of the film material is due tornbacterial enzyme digestion of the RS component of the film-coat in the colon. The digestion ofrnRS produces pores through the EC scaffold of the film which brings a release of the drugrncontent of the coated tablet only in the colon where these bacteria reside. rnBased on the above result, a film coating material from the local Teffâ€™s resistant starch couldrnbe isolated, prepared and evaluated to use it as a CTDDS in the pharmaceutical industry.