Antitrypanosomal Activity Of Hydromethanol Extract Of Leaves Of Cymbopogon Citratus And Seeds Of Lepidium Sativum In-vivo Mice Model

Trypanosomiasis is one of the neglected tropical diseases of both humans and animals caused rnby the protozoa Trypanosomes mainly endemic in Africa. Unavailability of vaccine, difficultyrnof vector controls, low therapeutic index of the available trypanocidal drugs, and developmentrnof resistance lead to the need for research focused on developing alternative safer, morerneffective and more accessible treatment options especialy from medicinal plants. In Ethiopia,rnmany medicinal plants such as Cymbopogon citratus and Lepidium sativum are used forrntreatment of trypanosomiasis as traditional remedies. The objective of the present study was,rntherefore, to investigate antitrypanosomal activities of leaves of C. citratus and seeds of L.rnsativum in in vivo mice model. The acute toxicity result showed that the extracts were safe atrnthe dose of 2000mg/kg, and the test doses were adjusted to 100, 200 and 400mg/kg based onrnthe toxicity profile. The Plants extracts were administered to the respective groups of micernafter the 12rnthrn days of T. congolense inoculation where the peak parasitemia were achieved.rnThe treatment continues consecutively up to seven days and the parameters were recordedrnevery other day up to the 14rnthrn day of treatment commenced. The in vivo test results revealedrnthat both plant extracts had dose dependent antitrypanosomal activity. Both crude extractsrnshowed a significant reduction in parasite load (P

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