Anti-ulcer Activity Of Aqueous Root Extract Of Ensete Ventricosum (welw.) Cheesman (musaceae) In Experimental Rats

Peptic ulcer is a chronic disease of gastrointestinal system caused by an imbalance betweenrndamaging factors and protective factors. Even though many antiulcer drugs used to treat thisrndisease are available, most of these drugs produced undesirable side effects, microbial resistancernand danger of drug interactions during therapy. An ethnobotanical study showed that Enseternventricosum is used for treatment of peptic ulcer but the efficacy and safety are not established.rnThus, this study was aimed to evaluate the anti-ulcer activity of aqueous root extract of Enseternventricosum (E. ventricosum) in experimental rats. The effect of the extract on gastric ulcer wasrnevaluated against indomethacin, ethanol and pyloric ligation-induced ulcer models at doses of 100,rn200 and 400mg/kg. Dose levels were selected based on outcome of acute toxicity study.rnPantoprazole at a dose of 40mg/kg was used as a standard drug while distilled water was used asrnnegative control. In indomethacin and ethanol-induced ulcer, pretreatment with aqueous rootrnextract of E. ventricosum significantly reduced level of gastric mucosal ulceration and improvedrnulcer protection. Furthermore, histopathological findings of rats pretreated with aqueous rootrnextract of E. ventricosum also revealed gastroprotective activity. In pyloric ligation-induced ulcer,rnadministration of E. ventricosum at a dose of 200 and 400mg/kg significantly (p

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