Ethiopia procures more than 16-billion-birr worth of pharmaceuticals and medical supplies perrnyear to more than 4000 public health facilities across the country but with very little considerationrnfor reverse logistics. In Ethiopia, the average wastage rate of medicines is 3.9%. In spite of thernefforts that the Ethiopian Ministry of Health and the Ethiopian Pharmaceutical Supply Agencyrnhave put in place to ensure efficiency in supply chain, and availability of medicines at all times,rnhowever, significant quantities of pharmaceuticals have been expiring in facility pharmacy storesrnand have been causing a challenge in supply chain system. The objective of the study is to assessrnthe implementation status and challenges of pharmaceutical reverse logistics in the case ofrnselected public hospitals in Addis Ababa, Ethiopia. Therefore, a descriptive cross-sectional studyrndesign and qualitative study was employed in six public hospitals in which 12 are key informantrninterviews. The quantitative data was collected through questionnaires, data abstraction formatsrnand checklist and analyzed using SPSS version 20 and Microsoft Excel 2016. The qualitative datarnwas collected through in-depth interview with the heads of the hospitals, pharmacy directoratesrnand pharmacy case team leaders and analyzed using thematic analysis. The results were presentedrnusing, graphs, percentages, mean scores, standard deviations and written texts. Majority of thernrespondents 47% agree that there is unclear reverse logistics practice in their respective hospitals.rnOverstocks are common at the hospital level, most hospitals 66% experience overstocks, 28%rnrarely experiences overstock and 6% experience no overstock. Redistribution has the highestrngrand mean score as compared to other reverse logistics activities such as recycling, recallingrnand disposal during the study period. Moreover, there is data invisibility to trace and track thernimplementation status of reverse logistics. This all, in turn made the public hospitals to turn theirrnface from the practical implementation of reverse logistics. Reverse logistics management shouldrnget attention in the pharmaceuticals supply system of the country for the proper management ofrnunused medications for disposal and usable for redistribution. It is recommended to give trainingrnfor pharmacy professionals on proper quantification of pharmaceuticals and attention must berngiven to the whole picture of reverse logistics rather than sticking only to waste management.rnOtherwise, the negative impact of reverse logistics may end up in financial loss to health sectorrnand environmental unfriendliness.