Treatment Outcome Of Neonatal Sepsis And Associated Factors Among Neonates Admitted To Neonatal Intensive Care Unit Of Tikur Anbessa Specialized Hospital Addis Ababa Ethiopia A Retrospective Cohort Study.

Globally, neonatal sepsis is a major cause of neonatal death. A definitive early diagnosis andrnappropriate antimicrobial therapy which significantly reduce mortality are challenging inrnresource limited settings like Ethiopia. This study aimed to assess the treatment outcomernand factors associated with neonatal sepsis mortality among those treated at the neonatalrnintensive care unit of Tikur Anbessa referral hospital (TASH), Addis Ababa, Ethiopia. Arnretrospective cohort study was conducted from September, 2018 to September, 2020.Neonatesrndiagnosed with sepsis by the attending physician either clinically or laboratory-confirmation wasrnincluded in the study. Data such as patient’s age, sex, and address, type of antimicrobialrnadministered, date of treatment started and completed, microbiological results and other clinicalrncharacteristics were collected retrospectively from medical chart. Data were entered andrnanalyzed using the Statistical Package for Social Sciences version 25. Survival analysis wasrnperformed using Kaplan Meier Method. Log-rank test was used to determine survival periodrndifferences and cox hazard regression was used to identify associated factors of neonatalrnmortality. Systematic random sampling technique was employed to recruit the study participants.rnBinary logistic regression was used to predict determinants of length of hospital stay. Statisticalrnsignificance was declared at p-value

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