Background: Malaria is a major public health problem and the leading communicable disease inrnEthiopia. Interruption of contact between humans and mosquitoes through the use of insecticidetreatedrnbed nets (ITNs) is a promising approach to protect people from malaria infection.rnTreatment failures and mortality due to malaria has risen in recent years, probably due tornincreasing resistance to anti-malarial medicines. Improper drug storage and rampant selfmedicationrnare some of the factors that may contribute to an increase in the development of drugrnresistance by malaria parasites towards anti-malarials.rnStudy objective: To assess the utilization pattern of anti-malarial drugs, and mosquito netrncoverage in Pawe special Woreda, Beneshangul-Gumuz National Regional State.rnMethodology: The study was conducted in Pawe Special Woreda, Beneshangul-GumuzrnRegional State between August and September 2008. Both quantitative and qualitative methodsrnwere employed in the data collection. Qualitative methods employed include focus grouprndiscussions and key-informant interviews. The quantitative method used is a community basedrncross-sectional household survey. The study utilized a trained interviewer administeredrnquestionnaire for data collection. Data was collected primarily from mothers. Quantitative datarnwas entered using EPI-Info software Version 6.04 and analyzed by SPSS version 11 statisticalrnpackages. Qualitative data were analysed through thematic content analysis in an attempt tornanswer key questions of the study.rnResults: Perceived malaria prevalence was found to be 6.1 %. Sixty nine, (38.8%) of those withrnreported malaria/symptom complexes in the last two weeks preceding the interview date se lfmedicatedrnthemselves with anti-malarials. Households with a family size of less than or equal torn5 persons (OR=0.47, CI=0.25, 0.90, P=0.02) were less likely to self-care with anti-malarials thanrnthose with a family size of more than 5 persons.