Introduction: Ethiopia experiences a heavy burden of infectious diseases with a growingrnprevalence of disease morbidity and mortality. With the increased intensity of antimicrobialrnuse following the increased burden of infectious disease in Ethiopia, AMR remains being arnhuge concern in the progress of treating infectious diseases. Health care facilities, particularlyrnthose which provide service to large number of patients, are a focal point in the emergence ofrnAMR.rnObjectives: To assess the AMR containment practices in selected public hospitals of AddisrnAbaba, Ethiopia.rnMethods: Cross sectional survey was conducted in six selected public hospitals of AddisrnAbaba, Ethiopia between September and November, 2013. The study involved the use ofrnmixed method approach. Quantitative data was collected by using structured selfadministeredrnquestionnaires whereas the qualitative data collection methods employed keyrninformant interviews and an observation using check list.rnResults: Of those approached 763 healthcare professionals, 667 completed the surveyrnquestionnaires making up 87.4% response rate. The study revealed that as many as 321rn(48.1%) of the total respondents had poor knowledge on AMR containment. Physicians andrnnurses were found to have the largest and lowest proportion of good knowledge levelrnrespectively. A significant association (p