Myrrh Resin (commiphora Myrrha) As Rate Controlling Excipient In Sustained Release Matrix Tablets Of Theophylline Evaluation Formulation And Optimization Study

Myrrh is an oleo-gum resin, obtained from the stem of various species of Commiphora, FamilyrnBurseraceae. The chief source is Commiphora myrrha. Myrrh is phytotoxically safe raw materialrnin industries like pharmaceuticals and food industries. The plant based excipients have beenrnstudied for their application in different pharmaceutical dosage forms like matrix sustainedrnrelease system.rnTheophylline is used as bronchodilator in the management of asthma and chronic obstructivernpulmonary disease. Its narrow therapeutic index (10-20 μg/ml) requires suitable formulationrnstrategies and sustained-release oral formulations have emerged as the most useful approach.rnThe aim of this study was to investigate the myrrh resin from Commiphora myrrha as a raterncontrolling excipient for sustained release matrix tablets of theophylline.rnThe moisture content and total ash values of myrrh resin was found to be 4.67±0.577% andrn0.24±0.047%, respectively. The sustained release matrix tablets of theophylline were preparedrnby wet granulation technique using myrrh resin as rate controlling excipient. The hardness ofrndifferent formulations were found to be between 89.8±2.86 and 133.7±3.53N while all tabletsrnhave passed the friability test (

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