Evaluation Of The Diuretic Activity Of The Aqueous And 80 Methanolic Extracts Of The Leaves Of Ajuga Remota B. In Mice

In the Ethiopian traditional medicine the leaves of Ajuga remota (Local name ‘Armagusa’) is used as diuretic agent. Since the diuretic activity of this plant had not been investigated in scientifically controlled studies, the aim of the present study was to evaluate the diuretic potential of the aqueous and hydroalcoholic extracts of the leaves of A. remota in mice after acute oral administration. Adult mice were administered orally either aqueous (250 mg/kg, AA250; 500 mg/kg, AA500 and 1000 mg/kg, AA1000) or 80% methanolic (250 mg/kg, AM250; 500 mg/kg, AM500 and 750 mg/kg, AM750) extract and urine output and electrolyte contents were quantitated up to 5 h and compared with those administered with furosemide 10 mg.kg (F10) and distilled water (CON). The hydroalcoholic extract increased diuresis significantly (p

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