In this work, a high intensity gradient laser was used to study the threshold ionization energy,rnthe threshold radiation dose, and the charge (to determine hemoglobin quantitation) of fourrndi erent samples of hemoglobin type. The study was conducted using AS, AC, FA or AF, andrnFSC hemoglobin types were obtained from MSCC at the MMC. The experiment was performedrnfor each cell, for a total of 62 cells for Hb AS, Hb FA, and Hb FSC, and 47 cells for Hb AC,rnwere trapped and ionized by a high intensity infrared laser at 1064 nm. With the laser traprnserving as a radiation source, the cell underwent dielectric breakdown of the membrane. Whenrnthis process occurs, the cell becomes highly charged and its dielectric susceptibility changes.rnThe charge creates an increasing electrostatic force while the changing dielectric susceptibilityrndiminishes the strength of the trapping force. Consequently, at some instant of time the cellrngets ejected from the trap. The time inside the trap (ionization time) while the cell is beingrnionized is used to determine the threshold ionization energy and threshold radiation dose, andrnthe intensity of radiation and the post ionization trajectory of the cells are used to determine thernthe charge for each cell of four di erent samples of hemoglobin type using NonlinearModelFit inrnMathematica. Laser tapping technique is indeeded promissing for a very precise measurementrnof the hemoglobin types present in a blood sample. Knowing the hemodlobin type present in arnblood sample is essential in screening sickle cell diseases and will vastly improve the accuracy ofrnmonitoring a sickle cell anemia patients receiving various types of treatments