Evaluation Of The Diuretic Activity Of The Aqueous And 80 Methanolic Extractsof The Leaves Of Medicago Sativa L.( Fabaceae) In Mice

Diuretics are therapeutic agents that are used to increase the rate of urine flow and sodiumrnexcretion in order to adjust the volume and composition of body fluids or to eliminate excess ofrnfluids from tissues. Most diuretic agents available in the market present a wide range of problemsrnsuch as efficacy and undesired effects. These limit their clinical usefulness and remain to bernsolved, leaving an open door for new and better compounds. Medicago sativaL.( Fabaceae)isrnused as diuretic in traditional medicine practice, but the plant has not been scientificallyrnevaluated for the claimed activity.The present study was therefore conducted to evaluaternthediuretic activity of the aqueous and 80% methanolextracts of the leaves of Medicago sativarnL.( Fabaceae) in mice.Extraction of the leaves of Medicago sativa was performed usingrnsuccessive maceration. Male mice were treated with vehicle (distilled water or 2% tween 80),rnstandard (hydrochlorothiazide 10 mg/kg) and three doses (250 mg/kg, 500 mg/kg, and 1000rnmg/kg,) of aqueous, and 80% methanol extract. Parameters, including urine volume, electrolyternconcentration, and pH were measured and analyzed. The aqueous and80% methanolextractsrnsignificantly increased (p

Get Full Work

Report copyright infringement or plagiarism