Lantana camara L. is one of the medicinal plants traditionally used for the treatmentrnof diarrhea in Ethiopia. Although the antidiarrheal activity of the crude extract of thernleaves of this plant was evaluated elsewhere, no work has been performed in thernEthiopian plant. The aim of this study was therefore to further confirm thernantidiarrheal activity of 80% methanol extract and fully evaluate the solvent fractionsrnusing mice model of diarrhea. The 80% methanol extract was prepared by macerationrnand the fractions were obtained by successive soxhlet extraction with chloroform andrnmethanol followed by maceration of the marc with water. The antidiarrheal activity ofrnthe extract and fractions were investigated using castor oil induced diarrhea (for 80%rnmethanol extract), enteropooling and small intestine transit models (the three modelsrnfor the fractions). The test groups received various doses (100, 200 and 400 mg/kg) ofrnthe extract or fractions, whereas positive controls received Loperamide (3 mg/kg) andrnnegative controls received vehicle (2% tween 80 or distilled water, 10 ml/kg). In therncastor oil induced diarrheal model, the 80% methanol extract delayed onset ofrndefecation, at 200 mg/kg and 400 mg/kg, and reduced the number and weight of fecesrnat all tested doses significantly as compared to the negative control. In this model thernmethanol and aqueous fraction at all tested doses and chloroform fraction at 200rnmg/kg and 400 mg/kg significantly reduced the number and weight of wet feces whenrncompared with negative control. In the enteropooling test, the methanol and aqueousrnfractions significantly reduced the weight and volume of intestinal fluid at all testedrnivrndoses, whereas the chloroform fraction significantly reduced the weight of intestinalrncontent only at 400 mg/kg when compared to negative control. Results from therncharcoal meal test revealed that all the fractions produced a significant anti-motilityrneffect at all tested doses as compared to negative control. This study confirmed thernantidiarrheal activity of the crude extract and further revealed all the three fractionsrnpossessed varying degree of antidiarrheal activity, with the methanol fraction beingrnthe most active fraction in all the three models.rnKey words: antidiarrheal activity, castor oil induced diarrhea, anti-enteropooling