Evaluation Of The Antidiarrheal Activity Of 80 Methanol Extract Of The Aerial Parts Of Ajuga Remota Benth In Mice

In the Ethiopian traditional medicine, the aerial parts of Ajuga remota Benth ( Localrnname, Armagusa) is used in the treatment of diarrhea. Since this claim has not beenrninvestigated scientifically, this study was undertaken to evaluate the anti-diarrhealrnactivity of 80% methanol extract of A. remota (MEAR) using experimental models inrnmice . The MEAR was administered at doses of (200, 400, 600 and 800 mg/kg ) to fourrngroups of mice (six animals per group) orally in castor oil diarrhea model. Two otherrngroups , one as control and the other as standard ( loperamide 5mg/kg ) were used forrncomparison with the treatment group. The effect of the extract on the other models,rnenteropooling and gastrointestinal transit models, was also evaluated using the samerngrouping and dosing . The extract at doses of 400, 600, and 800 mg/kg produced a dosedependentrnand significant inhibition both on the frequency and onset of diarrhea. Thernpercentage purging frequency was 53.4%, 66.7%, 79.6% (p < 0.001; for all), and 66.7%rn(p < 0.001) at three doses of MEAR (400, 600, and 800mg/kg ) and with loperamidern(5mg/kg ), respectively. The percentage inhibition in intestinal fluid accumulation wasrn42.5%, 62.1% , and 74.2% ( p < 0.001; for all ) at doses of 400, 600 and 800 mg/kg ofrnMEAR, respectively. The MEAR also inhibited significantly (p

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