Infectious diseases are the leading causes of mortality and morbidity in developing countries.rnManagement of infectious disease requires potent and effective antimicrobial drugs to which thernvirulent organisms are susceptible.. A retrospective cross-sectional study was done by reviewingrn1500 microbiology records from September, 2009 to August, 2014. From 1500 microbiologyrnrecords, 1086 bacteria were isolated. Among these (4.9%) were mixed infection . The mostrncommon isolated bacteria were S. aureus and P. aeruginosa with an isolation rate of (17.3)rnand (14.3%) respectively. About 47.4 % of S.aureus was oxacillin/methicillinresistantrn(MRSA).Ontheother hand, the resistance rate of S. aureus was lower to ceftriaxone 172rn(19.8%).rnS. pyogenes was resistant to tetracycline while lower resistance was observed tornerythromycin,. The highest resistance rate of P. aeruginosa and E. coli were found tornampicillin and amoxicillin. From multidrug resistant bacteria, majority were gram negativernamong which P. aeruginosa (97.7%) was the highest followed by E. coli (95.1%). Amongrngram positive MDR bacteria S.aureus (89.1%) was the highest followed by S. epidermidisrn(87.5%). The findings of this study show that there is high resistance rate of bacterial isolates tornthe commonly used antimicrobials. To benefit maximum antimicrobial effect from the activernantimicrobials and to reserve the threatened ones rational use of antimicrobials should bernpracticed.rnKey Words: Antimicrobial Resistance, Antibiotic Susceptibility, Bacterial Isolates.