Background: There is little information on the degreeof self-stigma experienced by patients withrnmood disorder across Ethiopia. This study describes the levels of self-stigma, stigma resistance,rnself esteem and the level of disability reported in these groups who had follow up as outpatient inrnPsychiatry clinic at St. Paulâ€™s Hospital, Addis Abeba, Ethiopia.rnMethods: Facility based cross-sectional study was conducted on 235 consecutive samples ofrnpeople with mood disorder using interviewer administered (ISMI) scale. Data was entered andrnanalysis was done using SPSS version 20. Bivariate and multivariate linear regressions wererndone to identify correlates of self stigma.rnResults:Almost one in three patients (31.5%) reported moderate or high levels of self-stigma,rn(54.9%) had moderate or high stigma resistance score, (67.2%) hadmoderate or high selfrnesteem,(27.7%) had moderate to high level of discrimination experience and One fourth of themrn(26.4%) had moderate to severe or extreme disability. And also,Females had higher self stigmarn(std. Î² = .169 with P < 0.01) than males and good adherence to medication was significantlyrncorrelated with lower self stigma (std. Î² = -.212 with P < 0.01) when compared with nonrnadherence. In a multivariate linear regression model (60%) of the variancein self-stigma scores,rnamong people with a diagnosis of bipolar disorder or depression, wasaccounted for by levels ofrnself esteem and stigma resistance.rnConclusions: These findings suggested that self-stigma occurs among approximately 1 in 3rnpeople with mood disorder in urban city of Ethiopiawhich was much higher than the findings inrnEurope. Female showed higher self stigma than male. So, Patient empowerment, psychosocialrninterventions and psychoeducation to increase compliance to medication can be helpful inrnreducing self stigma among people with mood disorder.