Adherence To Antiretroviral Therapy In Currently Changed Treatment Guideline On People Living With Hivaids At Bishofitu Hospital East Shoa 2011. Ethiopa.

Background:rnAdherence to antiretroviral therapy (ART) is crucial to ensure viral suppression, decrease the risk ofrndisease progression and drug resistance. Non-adherence to ART, likewise, is common in all groups ofrntreated individuals & lack of strict adherence to ART is considered to be one of the key challenges tornAIDS care worldwide.rnObjective:rnTo assess adherence to ART on currently changed guideline and factors associated with it amongrnPeople Living with HIV/AIDS (PLWHA) attending ART unit at Bishofitu Hospital.rnMethod:rnA cross sectional survey of 317 clients attending for ART at Bishofitu Hospital was carried out usingrnboth quantitative & qualitative design method. Using a structured and pre-tested questionnaire, data onrndrug adherence and other variables was collected through in-depth interview, peer educators FGD,rnpatient’s self report (interview), pill count and by reviewing their clinical records. The nurse & ARTrnClinician who are working in the ART unit were involved in data collection after being trained. Ethicalrnclearance was obtained from concerned bodies and consent was sought from the study subjects.rnAdherence is defined as the number of doses taken divided by the number of doses prescribed over arngiven period. It is considered as good if the patient took ≥ 95% of the prescribed doses correctly. Oddsrnratio was done to determine the strength of association for different variables.rnMajor FindingsrnThe overall prevalence of HAART adherence was found to be, 398(95.4%) in this study. The highestrnproportion, 61 % of patients missed or delayed their doses due to simply forgetting & 47.4% due tornbeing away from home & 29.4% being too busy. Independent positive predictors of HAART nonrnadherence reported in this study comprise:-the participants who had: PLWHA’s residency far fromrnBishofitu hospital (>47 KM.), depression feelings , ART eligibility knowledge, medication adverserneffect, history active substance uses, no adequate social support & one or two children under their carernin the final adjusted multivariate analysis.rnConclusions & Recommendations:rnThe prevalence of ART adherence among clients using currently changed single combinedrnfixed dose in this study was found higher than most studies done in developed countries & evenrnmuch higher than the findings of other studies in Ethiopia. From these, we can infer that single &rnsimplified ART has reduced the pill burden & helped the clients to take it at ease & this has increasedrnthe level of adherence behavior of clients, therefore continuous effort should be made to increasernclients’ awareness to maintain the best level of adherence outcomes.

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