Background: Depression affects a large proportion of the global population. It is reported tornaffect about a quarter of pregnant women in Ethiopia. Some studies indicate that anemia mightrnbea risk factor for depression. This underscores the need for an iron-folic acid supplementrn(IFAS). IFAS adherence by pregnant women is however not satisfactory. Studies again implicaternthat depression might affect adherence to IFAS. Nevertheless, thispotential vicious cycleis not arnwell-explored area of research. The objective of this study is therefore to assess the associationrnof antenatal depression with anemia and adherence to IFAS among pregnant women attendingrnantenatal care (ANC) at selected health centers.rnMethods: a facility-based cross-sectional study was conducted among pregnant women whornattended ANC service in Yeka sub-city, Addis Ababa. A total of 406 pregnant women werernrecruited in the study. Patient health questionnaire (PHQ-9), a validated tool in Ethiopia, wasrnused to assess antenatal depression. IFAS adherence was assessed using pill count method.rnBivariableand subsequent multivariable logistic regression were employed for data analysis.rnResults: it was found that anemic pregnant mothers had an increased odds of having antenatalrndepression [AOR=2.63; 95% CI (1.13, 6.14)] compared to non-anemic mothers. Having financialrnhardship, whether current pregnancy is planned and emotional abuse from an intimate partnerrnalso significantly associated with antenatal depression. Antenatal depression at cut-off (PHQ-rn9â‰¥5) failed to show statistically significant association with IFAS adherence. Major depressionrn(PHQ-9â‰¥10) was however found to be significantly associated with adherence to IFASrn[AOR=1.97; 95% CI (1.09, 3.56)] in pregnant women. Besides, factors significantly associatedrnwith IFAS adherence were parity, knowledge of the use of IFAS and current pregnancyrncomplication.rnConclusion: the study revealed a significant association that exists between two important publicrnhealth problems, anemia and antenatal depression; and the association between antenatalrndepression and IFAS adherence. Further investigation of these associations is a warranted area ofrnfuture studies. In the meantime, putting these underlying determinants into consideration isrnbeneficial as they might complicate diagnosis and have a negative impact on treatment outcomes.rn2rn1.