Hiv Seroconversion And Associated Factors Among Booked Seronegative Pregnant Women In Kobo Town And Raya Kobo Woreds North Wolloethiopia Institution Based Cross- Sectional Study.

Background: Under the current practice, pregnant women who were Human ImmunodeficiencyrnVirus (HIV) negative on the first test are considered to be HIV negative throughout. A repeatrnHIV test three months later would identify HIV seroconversion and ensure early intervention tornprevent mother to child transmission of the virus. The objective of this study is therefore tornmeasure the magnitude of HIV seroconversion and to identify factors associated with HIVrnseroconversion among booked first-time test seronegative pregnant women.rnMethods: An institution-based cross-sectional study was conducted among HIV negativernpregnant women in Kobo Town and Raya Kobo Woreda, North Wollo, Ethiopia from June tornJuly 2020. Data were collected using a questionnaire through face-to-face interviews along withrna client card review. HIV re-testing was performed to know the current HIV status of pregnantrnwomen. The collected data were entered into Epi data version 4.4.1 and were exported andrnanalyzed by SPSS version 25. A p-value < 0.25 in the bivariate analysis were entered in thernmultivariable logistic regression analysis and a p-value of < 0.05 was taken as statisticallyrnsignificant.rnResult: From a total of 494 pregnant women who were screened and reported negative for HIVrnat first ANC, six (1.2%) were HIV seropositive during retesting. Upon multivariable logisticrnregression, pregnant women who have had a reported history of sexually transmitted infectionsrn[AOR=7.98; 95% CI (1.206, 52.818)], participants’ partners reported travel history for workrnfrequently [AOR=6.00; 95% CI (1.093, 32.993)], and sexually abused pregnant womenrn[AOR=7.82; 95% CI (1.194, 51.243)] were significantly associated with HIV seroconversion.rnConclusion: The notable seroconversion rate found in this study implies that it is not enough torntest pregnant mothers once during the first antenatal care clinic. Rescreening of pregnant womenrnafter the booking is a beneficial strategy to allow the timely provision of ART prophylaxis tornHIV seroconverting women and their exposed babies for the elimination of mother to childrntransmission of HIV. Further expanded and large scale study should be conducted to understandrnthe magnitude and the factors of HIV seroconversion during pregnancy at various levels.

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