Background: WHO defined street food as food and beverages prepared and sold in thernstreet and other public places for immediate consumption.It is also described as the food thatrnis prepared either at home or along the street and consumed at the point of purchase orrnelsewhere without any processing.rnObjective: The objective of this study is toassess the hygiene practice of the vendors andrnsanitary conditions of the surrounding vending site with laboratory analysis of street food inrnthe Addis Ketema sub-city of Addis Ababa. rnMethods A total of 301 street food vendors were assessed by a structured questionnaire andrndirect observation in four selected sampling locations of Addis Ketema sub-city.rnAdditionally, the bacteriological quality of sixty samples of street food was determinedrnusing aerobic mesophilic bacterial count, total coliform, and Salmonella test. About 18rnquestions were set to measure street food vendor‟s hygiene practices. Vendors who scoredrnless than 12 points were considered poor and those who scored 12 points and abovernconsidered good hygiene practice. Independent variables were fit separately into a bivariaternlogistic model to evaluate the degree of association with the dependent variable. Thenrnvariables that havea p-value ≤0.2 were exported to a multivariable logistic regression model.rnThe strength of association was measured using OR and 95% CI and a p-value