Back ground: Menstrual hygiene management (MHM) is a process of managing menses wirnnecessary supplies and conditions by health and development promoted. Adolescents and youtespecially school girls in the rural area are the prime victims of MHM problems. MHM challengein low and middle income countries gain global attention recently. Generating context specifevidences would have paramount importance to design proper interventions. rnObjective: To assess menstrual hygiene management practice, associated factors and its effecamong school girls of Mida Woremo District in North Shewa, Amhara Region, Ethiopia, 2019/20rnMethod: School based cross-sectional study design with stratified sampling procedure waapplied. Samples were selected by lottery method from each stratum. Data was collected by selrnadministered questionnaire, FGDs and observation. Data was entered to Epidata version 4.6.2 anexported to SPSS version 25 for analysis. Both descriptive and binary logistic regressioconducted for quantitative and thematic analysis for qualitative part. Association expressed terms of COR and AOR with 95% CI by using p-value