Abstract rnBackground: Quality of life (QOL) is increasingly recognized as an important patient-reportedrnoutcome in health care research. However, the use is still restricted. Epilepsy impact was farrnmore frequently evaluated considering QOL but only focused on adult patients so this researchrnfocused on children. rnObjective: To assess the quality of life among children between (7-18) with epilepsy andrnassociated factors in governmental Hospitals in Addis Ababa, Ethiopia 2021. rnMethods: A facility-based cross-sectional study design was employed and data was collectedrnfrom 564 children using a face-to-face interview in Addis Ababa from November 2020 to rnJanuary 2021 selected using multi-stage sampling method. Probability proportionate to sizerntechnique was applied to select children from each hospital. The data was cleaned, enteredrnthrough EPI-INFO 3.1and exported to STATA version 15.0 for analysis. Frequency distributionsrnof variables were tabulated. The raw numbers of the five-point Likert scale for QOLIE-CH-48rndomain scores were converted into a 0-100-point response scale, with higher scores indicatingrnbetter QOL.ANOVA was used to assess the relationship between quality of life and thernindependent variables. Multiple linear regression was conducted to identify factors predictingrnquality of life. The threshold for statistical significance was p