Background: Cervical cancer is a leading cause of death from cancer among women in lowresourcernsettings, affecting women at a time of life when they are critical to social and economicrnstability. In addition to its magnitude, the economic and quality-of-life burden of cervical cancer isrnsignificant.rnObjectives: To estimate economic burden of cervical cancer among patients and their familyrnmembers and to determine predictors for variation in patient related cost of cervical cancer.rnMethods: Cost of illness study on 227 cervical cancer cases at Tikur Anbessa Hospital wasrnconducted. Consecutive sampling technique was used to select the study participants. We employed arnmicro-costing bottom-up approach in order to estimate direct cost of cervical cancer. Indirect costsrnfor the study subjects and their accompanying persons were calculated in terms of productivity timernlosses, using human capital approach. Societal perspective, prevalence-based model was used.rnDescriptive statistics such as mean, standard deviation, median and inter-quartile range wererncalculated to describe some parts of the results. Nonparametric testing; Kruskal Wallis was used torndetermine the statistical significance of the differences in mean values for the four stage of cervicalrncancer and other variables. Mann-Whitney test was used to determine the statistically significancerndifferences in mean values for the two groups (surgery, radiotherapy chemotherapy, ever admittedrnetc.). Multiple liner regression analysis was employed to analyze the separate effects of the variousrnpredictor variables on the cost of treatment.rnResults: The average outpatient cost per patient for cervical cancer was Birr 5,905 ($407.2) (medianrn= 3,000 ($206.9)). Mean direct outpatient cost (Birr 4,845.3 ($334.2) takes the largest sharerncompared with the indirect counterpart (Birr 2,173.7 ($150)). The outpatient cost for almost half ofrnthe respondent fails in a range between Birr 6,933 ($478) and Birr 1,359 ($93.7). Mean inpatient costrnfor hospitalized patients was Birr 5,863.2 ($404.4). The average direct inpatient cost was Birr 4,771rn($329) (74% medical costs and 26% non medical costs). The mean value for total inpatient cost forrnnearly half of the respondent were in a range of Birr 7,161($493.9) and 1,936 ($133.5). For everyrnsingle day increment in inpatient hospital stay there is equivalent increment of Birr 61.5 ($4.2) onrntotal inpatient patient side cost.rnConclusion: Cervical cancer creates an immense economic burden on patients and their families.rnOutpatient treatment cost was found to be dependent on patient residence distance from the hospital,rnnumber of employed household members, number of facility visited and occupation. Longer durationrnof inpatient hospital stay and existence of co-morbidity were associated with higher inpatient cost.rnKey words: cost of illness, cervical cancer, cancer, economic evaluation, cost, Ethiopia,