Back ground:-There are many reasons for children to under perform at school, such as,rnmedical problems including Intestinal parasitosis, below average intelligence, specificrnlearning disability, attention deficit, hyperactivity disorder, emotional problems, a poorrnsocio-cultural home environment, psychiatric disorders, or even environmental causesrnObjective: - The objective of this study was to assess the effect of Intestinal parasiticrninfection on academic performance of school children in Arb-Gebeya Town, T/GayintrnWoreda, S/Gondar, Ethiopia.rnMethods: - A cross sectional survey was conducted in school children for assessment ofrnthe effect of Intestinal Parasitic Infection on Academic Performance in Arb-GebeyarnTown. Sample sizes of 601 school children from grades 5th -8th were assessed usingrnstandardized, closed ended and coded questionnaire. In addition, physical examination,rnparasitological laboratory examinations and anthropometric measurements werernconducted to assess the nutritional status of the school children.rnResult: - Out of 601 students who had stool examination, 216 of them had at least onernparasite. Therefore, the overall Intestinal Parasitic Infection (IPI) rate (prevalence) wasrn216(35.9%). Of those, the dominant parasite was amoeba 80(13.3%), followed by ascarisrn50(8.3%). The presence of double infection was only 8(1.3%) and other parasites werernonly 15(2.5%). Students who had parasitic infection were less likely to achieve higherrnacademic performance than those who hadnâ€™t (OR 0.58, 95% CI 0.41-0.83). Thernprevalence of under weight (BMI below the 5th percentile) in the area was 30 (5%), 481rn(80%) had normal weight (BMI between the 5th and 85th percentile), 60 (10%) were atrnrisk of overweight (BMI value between 85th and 95th percentile). Thirty (5%) of studentsrnwere overweight. There was no any significant difference in being in a state of underrnweight between male (4.7%) and female (5.5%). Nutritional status didnâ€™t show anyrnassociation with academic performance(X2=6.046, P-value 0.109).rnConclusion: - Presence of Intestinal parasitic infection could affect school performancernnegatively. But the presence of one or more intestinal parasites did not indicate any effectrnor association with school performance. Underweight, overweight and obesity were lessrnprevalent. Nutritional status has no any effect on academic performance in the study.rnThus, it needs further investigation employing other techniques and study designs.