Background: HIV/AIDS has become the most devastating global epidemic the world hasrnever faced. Early knowledge of HIV infection is now recognized as a critical componentrnin controlling the spread of HIV infection and, for people with HIV infection, as an entryrnpoint for treatment, care and support.rnObjective: To identify the determinants of HIV-VCT acceptance in Gondar town,rnNorthwest Ethiopia.rnMethods: The study design was case-control, where the cases are those who acceptedrnVCT and the controls are those who did not accept VCT. A total of 115 cases and 230rncontrols from Gondar town were included in the study. The data was summarized andrnorganized using tables and texts. Associations between different exploratory variablesrnand outcome variable (VCT acceptance) was made using odds ratio with confidencernintervals. Multiple logistic regressions were used to show the impact of differentrndeterminants for VCT acceptance by controlling different confounders at the same time.rnP-value less than 5% was considered significant.rnResults: VCT acceptance was about seven times (OR = 6.91, 95% CI 1.21, 39.52) morernlikely to occur among unmarried than those who were divorced, separated and/orrnwindowed. VCT acceptance was less likely (OR = 0.03, 95% CI 0.01, 0.15) to occurrnamong students than those who were employed.rnVCT acceptance was about 4.75 times (OR = 4.75, 95% CI 1.05, 21.45) more likely tornoccur among those ever had sex than their counterparts. Those who had self-perceivedrnrisk and had knowledge of HIV/AIDS prevention methods were about 6 times (OR =rn6.08, 95% CI 1.89, 19.54) and 21.12 times (OR = 21.12, 95% CI 6.38, 69.95) more likelyrnto accept VCT than their counterparts respectively. VCT acceptance were less likely (ORrn= 0.03, 95% CI 0.01, 0.14) and (OR = 0.03, 95% CI 0.00, 0.42) to occur among thosernknow that a healthy-looking person can have the virus and those had knowledge of STIsrnrespectively than their counterparts.rnvirnAs to the problems related with VCT, those didn't know friends response was about 19rntimes (OR = 19.08, 95% CI 4.73, 77.00) more likely to occur among VCT acceptors thanrntheir counterparts, while didn't trust confidentiality of VCT services was less likely (ORrn= 0.19, 95% CI 0.06, 0.62) to occur among VCT acceptors than non-acceptors. VCTrnacceptance was less likely (OR = 0.06, 95% CI 0.02, 0.25) to occur among those said nornchange in relation to HIV positive partner than those said gradually separated.rnConclusions and recommendations: Those unmarried, had initiated sex, self-perceivedrnrisk, knowledge of HIV/AIDS prevention methods and don't know friend's response arernmore likely to accept VCT. Being a student, those know that a healthy-looking personrncan have the virus and those had knowledge of STIs are less likely to accept VCT. Thosernhad problems of don't trust confidentiality of VCT service and those have intention of nornchange in relationship to HIV positive partner are less likely to accept VCT. Efforts tornpromote VCT require education about the benefits of testing to students and women inrnparticular and all groups of individuals in general and organizing VCT service to makernmore acceptable to different groups of people is recommended.rnKey words: VCT-acceptance, Determinants of VCT, Gondar Town, Northwest Ethiopia.