Introduction:Central nervous system (CNS) defects are the second most common congenitalrnanomalies after congenital heart diseases. Neural tube defects (NTDâ€™s) are amongst the majorrnCNS defects with significant public health burden and long term morbidity and functionalrnimpairment. Central nervous system (CNS) defects are the second most common congenitalrnanomalies after congenital heart diseases. Neural tube defects (NTDâ€™s) are amongst the majorrnCNS defects with significant public health burden and long term morbidity and functionalrnimpairment. Many literatures recommend offering screening for NTDs to all pregnant women.rnAmniotic fluid AFP (AF-AFP) and amniotic fluid acetylcholinesterease (AChE) are the primaryrnbiochemical tests performed on amniotic fluid for detection of open neural tube defects. Thernother modality used for screening of these defects is prenatal ultrasound scan.rnMethod:This hospital based cross sectional prospective study tried to show the utility ofrnultrasound and the prevalence and pattern of occurrence of these defects.About total of 956rnpregnant mothers who came to the hospital were evaluated with ultrasound scan.rnResults:We found a total of 6 open NTDâ€™s out of this group. There were 2 anencephaly, 1 ChiarirnII, 1encephalocele and 1 had both anencephaly and spinabifida. Only 55 % if the respondentsrntook IFA supplement during pregnancy and of those who took the supplement 43% took it for arnmaximum of 1 week. Of the parameters we found TCD has a strong correlation with therncalculated mean gestational age.rnConclusion and recommendation:The above findings reflect a high incidence of these defects.rnThe low coverage of folic acid supplement as well as poorer socioeconomic factors all wouldrncontribute to the observed burden of the disease. Comprehensive screening and preventivernstrategies must be designed. Further studies and decisions policy maker level are necessary tornimprove the current figures.