This study has aimed to determine the Prevalence and Predictors of Anxiety and Depression among Cervical Cancer Patients at Tikur Anbessa Specialized Hospitals, Addis Ababa, Ethiopia. Institutional based Cross sectional study was conducted and convenient sampling technique was utilized to select study subjects and to determine sample size a single proportion formula was used. According to this formula the sample size of the study was 163. Pretest was done and data entered into Epi-data version 3.1 statistical software package then exported to SPSS software package version 21 for further analysis. Among the respondents involved in the study 117 (71.8%) of cervical cancer patients could developed depression and 31 (19%) were boarder line cases. whereas 15 (9.2%) of the respondents were free from depression. Cervical cancer patients those ages between 41 and 50 were 3.6 times more likely to have risk of anxiety (AOR=3.6 ;( 1.38, 9.48) compared to those ages above 50. The other variable that associated with anxiety was place of residence. Cervical cancer patients those live in rural areas were 1.3 times (AOR=1.3 ;( 1.03, 2.7) more likely to have risk of anxiety compared to cervical cancer patients those live in the urban areas. This study showed that high number of cancer patient developed anxiety and depression. As a recommendation there is a need to design and implement the ways to support cervical cancer patients to decrease their anxiety and depression.