Work- related stress is a reaction that occurs when the work weight progress towards becoming excessive. Therefore, unless properly managed stress leads to high employee turnover, decreased performance, illness and absenteeism. Yet, little has been addressed work -related stress and its predictors in the study area. Therefore, the objective of this study was to assess stress prevalence and its predictors in study area. To that effect, a cross-sectional study design was conducted on281 employees from Ethiopian Federal Bureau of Investigation by using stratified random sampling techniques. Survey questionnaire scales were employed to collect data. Data were analyzed by percentage, Pearson correlation coefficients, simple linear regression, multiple linear regressions, independent t-test and one way ANOVA statistical techniques. In the present study13.9% of participants face highly stress where as 13.5% of participants face low stress and the rest72.6% of officers experienced moderate stress. There is no significant group difference among workers due to ages, gender, marital status, educational level, years of service and police rank. This study conclude that factors such as role conflict, performance over utilization, role ambiguity, qualitative and quantitative role overload together predict 39.6% of work related stress. This indicates that 60.4% of variation in stress explained by other factors so other additional research should be done to identify additional factors predicting stress. To prevent occupational stress among police, Ethiopian Federal Bureau of Investigation should develop strategies based on factors that will help to develop stress reduction management.rnKeywords:work-relatedstress,FederalBureauofInvestigation,Predictors