Frontline health professionals are under a great deal of stress, including a high risk of suspected rnor confirmed COVID-19 infection, a potential resource shortage, as well as a job overload. The rnobjective was assess the magnitude of psychological distress and burnout among health rnprofessionals and statistically significant difference of health professionals who had contact rnhistory of COVID -19 suspected and/or confirmed patients during the (COVID-19) outbreak in rnMenillik II referral hospital. A descriptive survey was conducted using simple random sampling rntechniques with 272 of health professionals who has been working in Menellik-II referral rnhospital Addis Ababa, Ethiopia. An independent t-test and/or one-way ANOVA for testing rnvariation at 95% confidence interval and P-value < 0.05were used to compare means of rnindependent variables. A P-value less than 0.05 will consider being statistically significant in all rncases. Magnitude of burnout and psychological distress was assessed by validated English rnlanguage version of the Maslach Burnout Inventory and Kessler 10 scale respectively. Clean rndata was coded, entered, and analyzed by using computer software SPSS version 20. About 258rn(96.7% response rate) respondents completed the questionnaire and used for analysis. The rnparticipants were included 24% special or general doctor, 34.1% BSc nurse, 22.5% health rnofficer, 6.2% Midwifery, 4.3% Laboratory technician and 8.9% others types health rnprofessionals. A 229(88.7%) of health professionals were had a direct contact history with rnpatients of COVID-19 confirmed or suspected during work time. A health professionals who hadrncontact history of Covid-19 confirmed or suspected clients were developed 130(56.7%) rnmoderate, 90(39.3%) high and 2 (0.8%) very high psychological distress. As well as from health rnprofessionals who had contact history of Covid-19 confirmed or suspected clients were recorded rn88 moderate to high emotional exhaustion, 190 moderate to high depersonalization and 192 rnmoderate to high personal accomplishments. Male nurses, female Midwifery, male Laboratory rntechnician, and others types of female health professionals were recorded high prevalence of rnpsychological distress and burnout. There is a statistically significant difference in rnpsychological distress, personal accomplishment, and emotional exhaustion, but not in rndepersonalization scores between health profession types. There is a statistically significant rndifference in psychological distress and burnout scores between working areas or wards of the rnhealth profession. This study shows more than half of health professionals were categorized as rnhaving mild to severe psychological distress and burnout in related to the COVID-19 pandemic rnand other factors. About 0.8% of the health professionals in surveyed hospital considered that rnthey might need psychological or psychiatric treatment in the future. Regular assessment of the rnprevalence of burnout and psychological distress within hospitals and other health systems of rnhealth professionals in might help to identify risk factors or protective factors for burnout, rnpsychological distress and other mental disorders; this would benefit individuals and healthrnsystems/organization.