In Ethiopia poor health care infrastructure, stigma, low collaboration and coordinationrnamong agencies, and sustainability issues have endangered accessibility of AntiretroviralrnTreatment (ART) by PLWHA. Paramount among the stakeholders strategy to addressrnthese problems is advocacy using media as a significant tool. This research is arnquantitative and qualitative research based on survey and key-informants interview withrnART stakeholders of governmental organizations, non-governmental organizations,rnhospitals, US based universities, PLWHA associations and media agencies to investigaternchallenges, barriers and best practices of media advocacy to address accessibility of ARTrnsynergistically.rnAccording to the study, all stakeholders responded that there is a hugerninformation gap of ART among the public. More than 82% of the stakeholders arernengaged on advocacy and over 81% of them responded radio and/or TV is the bestrnchannel of advocacy tool. Even though 36% of the stakeholders responded that they havernproduced ART related broadcast messages, none of them are aimed to influence policiesrnand decision makers to advance services of ART. Over 58% of the stakeholdersrnresponded that collaboration among themselves and with the media agencies to undertakernvigorous media advocacy activities is not satisfactory. This study contrary to the fearrnappeal approach relies upon person-in-environment concept of social work and systemsrntheory to improve accessibility of ART at various systems level. The study concludedrnthat media advocacy practices by the stakeholders are limited and suggests mediarnadvocacy tool and recommendations for future directions