Autistic syndrome disorder is being revealed as one of the major problems in Ethiopia in recentrnyears. Nia Foundation Joy Center and Nehemiah autism center are the major actors in thernprovision of support for children with Autistic syndrome disorder and their families. This studyrnwas conducted to assess autism care and treatment service provision practice of existing servicernproviders in light of widely recommended practices and evidence based programming inrnEthiopia. The study adopted a cross sectional descriptive study involving 42 people selectedrnpurposively from teachers, professionals, parents and the centers management body. Thernresearch was qualitative in nature. The findings of the study revealed that the service packagesrnof the organizations are giving training on the area of autism and treating Autistic children. Therncenters also provide counseling and training services to parents and family members includingrnskill trainings. However, the services are primarily limited to awareness creation andrnconsultation on major issue based on the initiation from the parents/caregiver. The services arernguided by the individual knowledge and experience of the program managers rather than via arnstandardized manuals, guidelines and curriculum. The physical environment of the centers isrngood but very limited in terms of technology application and space adequacy. Demonstration,rnpositive reinforcement and use of tangible things in teaching the children were found to berneffective. The programs of both centers fail to be inclusive in the sense of facilitating interactionrnwith nondisabled children. Lack of a supportive environment, low level of public awarenessrnabout the issue, absence of well proven effective remedies to autism, shortage of knowledgeablernand skilled human resource were indicated to be major challenges. Increasing public awarenessrnand advocacy for expansion of service and academic institutions training program, enhancingrnthe involvement of spiritual leaders, leveraging with other actors via partnership andrncollaboration were suggested for improved impact. Besides, strengthening the review,rnmonitoring and evaluation of the interventions are recommended to come up with evidencernbased programming.