Mortality is one of the components of population change. Infant and child mOl1ality arernamong the best indicators of health development and socioeconomic status. Because arnsociety's life expectancy at birth is determined by the survival chances of infants andrnchildren. That is why reduction of infant and child mortality is a worldwide target andrnone of the most important key indicators of the Millennium Development Goals (MDGs).rnHence its indication is very important for evaluation and public health strategy.rnThe objective of this study was to examine the impact of maternal, socio economic andrnsanitation variables on infant and child mortality in Ethiopia and identify which of thesernfactors had a pronounced impact for the reduction of infant and child mortality. The datarnin this study were obtained fi'om the 2011 Ethiopia Demographic and Health surveyrn(EDI-IS, 2011) conducted by the Central Statistical Agency (CSA). To analyze the datarndescriptive statistics, univariate and multi variable analyses were used. The descriptivernanalysis indicates that a death proportion is lower for females (20.6%) than for malesrn(24.85%). Kaplan-Meier survival curves and log-Rank test were used to compare thernsurvival experience of different groups. Cox's regression model was employed to identifyrnthe covariates that had a statistical significant effect on the survival time of infants. Thernestimation of the model parameters was done by partial maximum likelihood procedures.rnMothers' educational level, birth order, sex and types of birth were identified as the riskrnfactors for the death of infants. Furthermore it was found that the survival probabilities ofrninfants with multiple birth, first birth order, non educated mothers and male children werernlow.