Application Of Cox Proportional Hazards Model In Case Of Tuberculosis Patients In Selected Addis Ababa Health Centers Ethiopia

Tuberculosis (TB) is a chronic infectious disease and mainly caused by mycobacteriumrntuberculosis (MTB). It has been one of the major causes of mortality in Ethiopia. Thernobjective of the study was to identify factors that affecting the survi val of the patientsrnwith tuberculosis who started treatment for tu berculosis. This was a retrospective study inrnsix randomly se lected health centers in Addis Ababa, Ethiopi a. The data were obtainedrnfrom med ical records ofTB pat ients regi stered from September 2012 to August 20 13 andrntreated under DOTS strategy. Out of the total 826 registered TB patients 105 ( 12.7 1%)rndi ed during the study period and 7 12(87.29%) were censored . Based on Kaplan Meierrnsurvival curves, log rank lest and Wi lcoxon tcst it was found that the patients hadrnstatistically significant d ifferences in survival experience with respect to age, bodyrnweight at initiation of treatment, TB patient category and HIV status. Multivariable Coxrnhazards regression anal ysis revea led that the covariates age, TB patient category, HIVrnand age by HIV interaction were significant risk factors associated with death status inrnTB patients.

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