Risk Factors Of Mortality Among Hivtb Co-infected Patients Under Art A Case Study In Change Health Center Northwest Ethiopia

HIV infection is a major risk factor for the development of tuberculosis (TB).rnTuberculosis is a cause of significant morbidity and mortality in patients with AIDS.rnThe objective of this study was to identify risk factors of mortality among HIV/TBrnco-infected patients in Chagni Health Center, Awi zone in Amhara Regional State,rnnorthwest Ethiopia. This is a retrospective study based on 510 cases of HIV-infectedrnTB patients of age 15 years and above who received anti-TB treatment betweenrnSeptember 1, 2010 and April 30, 2013 and were followed until July 31, 2013. ThernKaplan-Meier method was used to estimate survival time and Cox’s regression modelrnwas employed to identify covariates that have statistical significant effects on thernsurvival of HIV/TB co-infected patients. The descriptive analysis showed that out ofrn510 patients, 200 (39%) patients died during ART and anti-TB treatment period, ofrnthese 113 (56.5%) were females. 303 (59.4%) patients had ����4 ���������� ≤rn200 ����������/������, 272 (53.3%) patients were in the age group (15 − 30), 265 (52.2%)rnpatients were under-weight (������ ≤ 18.5) and 234 (45.9%) patients started treatmentrnon D4T-based drug regimens. The results of the multivariate PH Cox regressionrnanalysis showed that having cd4 count ≤ 200cels/mm3 at the start of ART,rnpresence of extra-pulmonary TB, being bedridden and WHO stage IV werernassociated with higher risk of mortality. On the other hand, those patients who tookrnAZT-based drug regimens and having normal-weight (18.5 kg/m2 < bmil

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